The Saskatoon Police Service guns and gangs unit executed a search warrant at a home on Avenue L South Thursday night.
Officers seized marijuana, cocaine and methamphetamine, along with weapons and ammunition.
Three people were arrested at the scene. Two 28-year-old men are facing trafficking charges and various weapons offences. A 26-year-old woman was arrested on warrant for breach of court order.
All three appeared in Saskatoon Provincial Court on Friday morning.